In molecular biology, central dogma illustrates the flow of genetic information from DNA to RNA to protein. It is defined as a process in which the information in DNA is converted into a functional product.
Dogma 11 Projects Pdf 11
Although genetics clearly play an important role in personalized medicine, the role of epigenetics should not be overlooked. Epigenetics refers to the phenomenon of heritable changes to gene regulation caused by mechanisms that do not involve modification of the nucleotide sequence. Increasingly, it is being realized that these mechanisms are far more complex than originally envisioned, requiring adjustment of the current perspective on the central dogma of molecular biology; namely, that DNA transcribes RNA, which is subsequently translated into protein [133]. It is estimated that approximately 98% of the human genome is not translated into protein, and these epigenetic changes occur within the framework of DNA being transcribed into both coding and non-coding RNA, with the subsequent translation of coding RNA into protein, and the concurrent regulation of each of these steps by non-coding RNA [134, 135] (Figure 2). Specific epigenetic mechanisms include DNA methylation, histone modification, alternative splicing, RNA editing, and non-transcriptional gene silencing via microRNAs [136]. Epigenetic regulation has been implicated in a myriad of neural processes, from learning and memory to seizures and neurogenesis, and recently to depression, chronic stress, and various addictions [137, 138].
Nicola Aceto: My lab is interested in metastasis. More than 90% of people with cancer die when metastasis happens. It is a big unsolved problem. We recently found that metastasis is driven mostly by clusters of circulating tumor cells (CTCs), which are multicellular aggregates of tumor cells that depart from the existing tumor, circulate in the bloodstream, and then metastasize. This finding challenged the prevailing dogma in the metastasis field, as until a few years ago, people thought metastasis happened one cell at a time. Thanks to new technologies, we could finally investigate blood samples from patients and in animal models, which allowed us to identify CTC clusters.
Keep in mind that CRM projects are fundamentally an organisational transformation process that, when successful, can change the entire face of the business and avail you of a generous ROI. And, to achieve that CRM success you need to manage your digital transformation process. In other words, you need to come up with a well-designed change management plan that touches on all aspects linked to user adoption.
MitoPathwayMitoPathways HierarchyHuman MitoCarta3.0 Genes Mitochondrial central dogmaMitochondrial central dogmaAARS2, ALKBH1, ANGEL2, APEX1, ATAD3A, ATAD3B, AURKAIP1, C12orf65, CARS2, CDK5RAP1, CHCHD1, COA3, COX14, DAP3, DARS2, DDX28, DHX30, DNA2, DUS2, EARS2, ELAC2, ENDOG, ERAL1, EXD2, EXOG, FARS2, FASTK, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GADD45GIP1, GARS1, GATB, GATC, GFM1, GFM2, GRSF1, GTPBP10, GTPBP3, GUF1, HARS2, HEMK1, HSD17B10, IARS2, KARS1, LACTB2, LARS2, LIG3, LRPPRC, MALSU1, MARS2, METAP1D, METTL15, METTL17, METTL4, METTL5, METTL8, MGME1, MIEF1, MPV17L2, MRM1, MRM2, MRM3, MRPL1, MRPL10, MRPL11, MRPL12, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL32, MRPL33, MRPL34, MRPL35, MRPL36, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL55, MRPL57, MRPL58, MRPL9, MRPS10, MRPS11, MRPS12, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MRRF, MTERF1, MTERF2, MTERF3, MTERF4, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTO1, MTPAP, MTRES1, MTRF1, MTRF1L, MUTYH, MYG1, NARS2, NGRN, NOA1, NSUN2, NSUN3, NSUN4, OGG1, OSGEPL1, OXA1L, PARS2, PDE12, PDF, PIF1, PNPT1, POLB, POLDIP2, POLG, POLG2, POLQ, POLRMT, PPA2, PRIMPOL, PRORP, PTCD1, PTCD2, PTCD3, PUS1, PUSL1, QRSL1, QTRT1, RARS2, RBFA, RCC1L, RECQL4, REXO2, RMND1, RNASEH1, RPUSD3, RPUSD4, SARS2, SLIRP, SSBP1, SUPV3L1, TACO1, TARS2, TBRG4, TEFM, TFAM, TFB1M, TFB2M, THG1L, TIMM21, TOP1MT, TOP3A, TRIT1, TRMT1, TRMT10C, TRMT2B, TRMT5, TRMT61B, TRMU, TRNT1, TRUB2, TSFM, TUFM, TWNK, UNG, VARS2, WARS2, YARS2, YBEY, YRDC mtDNA maintenanceMitochondrial central dogma > mtDNA maintenanceAPEX1, ATAD3A, ATAD3B, DNA2, ENDOG, EXOG, LIG3, METTL4, MGME1, MTERF1, MTERF2, MUTYH, OGG1, PIF1, POLB, POLDIP2, POLG, POLG2, POLQ, POLRMT, PPA2, PRIMPOL, RECQL4, RNASEH1, SSBP1, TFAM, TFB2M, TOP1MT, TOP3A, TWNK, UNG mtDNA replicationMitochondrial central dogma > mtDNA maintenance > mtDNA replicationDNA2, EXOG, LIG3, MGME1, POLG, POLG2, POLRMT, RNASEH1, SSBP1, TFAM, TFB2M, TOP1MT, TOP3A, TWNK mtDNA nucleoidMitochondrial central dogma > mtDNA maintenance > mtDNA nucleoidATAD3A, ATAD3B, MTERF1, MTERF2, POLDIP2, POLG, POLG2, POLRMT, SSBP1, TFAM, TWNK mtDNA repairMitochondrial central dogma > mtDNA maintenance > mtDNA repairAPEX1, EXOG, LIG3, OGG1, POLB, POLG, PRIMPOL, RECQL4, UNG mtDNA modificationsMitochondrial central dogma > mtDNA maintenance > mtDNA modificationsMETTL4 mtDNA stability and decayMitochondrial central dogma > mtDNA maintenance > mtDNA stability and decayENDOG, EXOG, MGME1 mtRNA metabolismMitochondrial central dogma > mtRNA metabolismALKBH1, ANGEL2, CDK5RAP1, DDX28, DHX30, DUS2, ELAC2, ENDOG, ERAL1, FASTK, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRSF1, GTPBP3, HSD17B10, LACTB2, LRPPRC, METTL15, METTL17, METTL5, METTL8, MRM1, MRM2, MRM3, MRPL12, MRPL47, MRPS7, MRPS9, MTERF1, MTO1, MTPAP, MTRES1, MYG1, NGRN, NOA1, NSUN2, NSUN3, NSUN4, OSGEPL1, PDE12, PNPT1, POLRMT, PPA2, PRORP, PTCD1, PTCD2, PUS1, QTRT1, RCC1L, REXO2, RMND1, RNASEH1, RPUSD3, RPUSD4, SLIRP, SUPV3L1, TBRG4, TEFM, TFAM, TFB1M, TFB2M, THG1L, TOP1MT, TRIT1, TRMT1, TRMT10C, TRMT2B, TRMT5, TRMT61B, TRMU, TRNT1, TRUB2, YBEY, YRDC TranscriptionMitochondrial central dogma > mtRNA metabolism > TranscriptionMRPL12, MTERF1, MTRES1, POLRMT, TEFM, TFAM, TFB2M, TOP1MT mtRNA granulesMitochondrial central dogma > mtRNA metabolism > mtRNA granulesALKBH1, DDX28, DHX30, ERAL1, FASTK, FASTKD1, FASTKD2, FASTKD5, GRSF1, HSD17B10, MRM1, MRM2, MRPL47, MRPS7, MRPS9, MTPAP, NOA1, PRORP, PTCD1, PTCD2, PUS1, RMND1, RPUSD3, RPUSD4, SUPV3L1, TFB1M, TRMT10C, TRUB2 Polycistronic mtRNA processingMitochondrial central dogma > mtRNA metabolism > Polycistronic mtRNA processingELAC2, FASTK, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRSF1, HSD17B10, PRORP, PTCD2, TBRG4, TRMT10C, YBEY mt-tRNA modificationsMitochondrial central dogma > mtRNA metabolism > mt-tRNA modificationsALKBH1, CDK5RAP1, DUS2, GTPBP3, HSD17B10, MTO1, NSUN2, NSUN3, OSGEPL1, PUS1, QTRT1, RPUSD4, THG1L, TRIT1, TRMT1, TRMT10C, TRMT2B, TRMT5, TRMT61B, TRMU, TRNT1, YRDC mt-rRNA modificationsMitochondrial central dogma > mtRNA metabolism > mt-rRNA modificationsMETTL15, METTL17, METTL5, MRM1, MRM2, MRM3, MTPAP, MYG1, NGRN, NSUN4, RCC1L, RPUSD3, RPUSD4, TFB1M, TRIT1, TRMT2B, TRMT61B, TRUB2 mt-mRNA modificationsMitochondrial central dogma > mtRNA metabolism > mt-mRNA modificationsANGEL2, MTPAP, MYG1, PDE12 mtRNA stability and decayMitochondrial central dogma > mtRNA metabolism > mtRNA stability and decayENDOG, FASTK, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRSF1, LACTB2, LRPPRC, MTPAP, PDE12, PNPT1, REXO2, RNASEH1, SLIRP, SUPV3L1, TBRG4 TranslationMitochondrial central dogma > TranslationAARS2, AURKAIP1, C12orf65, CARS2, CHCHD1, COA3, COX14, DAP3, DARS2, DDX28, DHX30, EARS2, ERAL1, EXD2, FARS2, FASTKD2, GADD45GIP1, GARS1, GATB, GATC, GFM1, GFM2, GRSF1, GTPBP10, GUF1, HARS2, HEMK1, IARS2, KARS1, LARS2, LRPPRC, MALSU1, MARS2, METAP1D, METTL17, MIEF1, MPV17L2, MRM2, MRM3, MRPL1, MRPL10, MRPL11, MRPL12, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL32, MRPL33, MRPL34, MRPL35, MRPL36, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL55, MRPL57, MRPL58, MRPL9, MRPS10, MRPS11, MRPS12, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, MRRF, MTERF3, MTERF4, MTFMT, MTG1, MTG2, MTIF2, MTIF3, MTRES1, MTRF1, MTRF1L, NARS2, NGRN, NOA1, NSUN4, OXA1L, PARS2, PDF, PPA2, PTCD3, PUSL1, QRSL1, RARS2, RBFA, RMND1, SARS2, SLIRP, TACO1, TARS2, TFB1M, TIMM21, TRMT61B, TSFM, TUFM, VARS2, WARS2, YARS2, YBEY Mitochondrial ribosomeMitochondrial central dogma > Translation > Mitochondrial ribosomeAURKAIP1, CHCHD1, DAP3, GADD45GIP1, MRPL1, MRPL10, MRPL11, MRPL12, MRPL13, MRPL14, MRPL15, MRPL16, MRPL17, MRPL18, MRPL19, MRPL2, MRPL20, MRPL21, MRPL22, MRPL23, MRPL24, MRPL27, MRPL28, MRPL3, MRPL30, MRPL32, MRPL33, MRPL34, MRPL35, MRPL36, MRPL37, MRPL38, MRPL39, MRPL4, MRPL40, MRPL41, MRPL42, MRPL43, MRPL44, MRPL45, MRPL46, MRPL47, MRPL48, MRPL49, MRPL50, MRPL51, MRPL52, MRPL53, MRPL54, MRPL55, MRPL57, MRPL58, MRPL9, MRPS10, MRPS11, MRPS12, MRPS14, MRPS15, MRPS16, MRPS17, MRPS18A, MRPS18B, MRPS18C, MRPS2, MRPS21, MRPS22, MRPS23, MRPS24, MRPS25, MRPS26, MRPS27, MRPS28, MRPS30, MRPS31, MRPS33, MRPS34, MRPS35, MRPS36, MRPS5, MRPS6, MRPS7, MRPS9, PTCD3 Mitochondrial ribosome assemblyMitochondrial central dogma > Translation > Mitochondrial ribosome assemblyDDX28, DHX30, ERAL1, FASTKD2, GRSF1, GTPBP10, MALSU1, METTL17, MIEF1, MPV17L2, MRM2, MRM3, MTERF3, MTERF4, MTG1, MTG2, NGRN, NOA1, NSUN4, PTCD3, RBFA, TFB1M, TRMT61B, YBEY Translation factorsMitochondrial central dogma > Translation > Translation factorsC12orf65, COA3, COX14, GFM1, GFM2, HEMK1, MRPL58, MRRF, MTIF2, MTIF3, MTRF1, MTRF1L, TACO1, TIMM21, TSFM, TUFM mt-tRNA synthetasesMitochondrial central dogma > Translation > mt-tRNA synthetasesAARS2, CARS2, DARS2, EARS2, FARS2, GARS1, GATB, GATC, HARS2, IARS2, KARS1, LARS2, MARS2, NARS2, PARS2, QRSL1, RARS2, SARS2, TARS2, VARS2, WARS2, YARS2 fMet processingMitochondrial central dogma > Translation > fMet processingMETAP1D, MTFMT, PDF Protein import, sorting and homeostasisProtein import, sorting and homeostasisAFG1L, AFG3L2, AGK, AIFM1, ATAD1, ATP23, CASP3, CASP8, CASP9, CHCHD4, CLPB, CLPP, CLPX, DNAJA3, DNAJC11, DNAJC15, DNAJC19, DNAJC4, DNLZ, FKBP10, GFER, GRPEL1, GRPEL2, HSPD1, HSPE1, HTRA2, IDE, IMMP1L, IMMP2L, LACTB, LAP3, LONP1, MAIP1, METAP1D, MIPEP, MTX1, MTX2, MUL1, NLN, NRDC, OMA1, OXA1L, PAM16, PARK7, PARL, PDF, PHB, PHB2, PITRM1, PMPCA, PMPCB, PRSS35, ROMO1, SAMM50, SPG7, STOML2, TIMM10, TIMM10B, TIMM13, TIMM17A, TIMM17B, TIMM21, TIMM22, TIMM23, TIMM29, TIMM44, TIMM50, TIMM8A, TIMM8B, TIMM9, TOMM20, TOMM20L, TOMM22, TOMM34, TOMM40, TOMM40L, TOMM5, TOMM6, TOMM7, TOMM70, TRAP1, UQCRC1, UQCRC2, USP30, XPNPEP3, YME1L1 Protein import and sortingProtein import, sorting and homeostasis > Protein import and sortingAGK, AIFM1, CHCHD4, DNAJC11, DNAJC15, DNAJC19, GFER, GRPEL1, GRPEL2, IMMP1L, IMMP2L, MIPEP, MTX1, MTX2, NRDC, OXA1L, PAM16, PMPCA, PMPCB, ROMO1, SAMM50, TIMM10, TIMM10B, TIMM13, TIMM17A, TIMM17B, TIMM21, TIMM22, TIMM23, TIMM29, TIMM44, TIMM50, TIMM8A, TIMM8B, TIMM9, TOMM20, TOMM20L, TOMM22, TOMM34, TOMM40, TOMM40L, TOMM5, TOMM6, TOMM7, TOMM70, UQCRC1, UQCRC2, XPNPEP3 TOMProtein import, sorting and homeostasis > Protein import and sorting > TOMTOMM20, TOMM22, TOMM34, TOMM40, TOMM40L, TOMM5, TOMM6, TOMM7, TOMM70 SAMProtein import, sorting and homeostasis > Protein import and sorting > SAMMTX1, MTX2, SAMM50 MIA40Protein import, sorting and homeostasis > Protein import and sorting > MIA40AIFM1, CHCHD4, GFER TIM22 carrier pathwayProtein import, sorting and homeostasis > Protein import and sorting > TIM22 carrier pathwayAGK, TIMM22, TIMM29 TIM23 presequence pathwayProtein import, sorting and homeostasis > Protein import and sorting > TIM23 presequence pathwayROMO1, TIMM17A, TIMM17B, TIMM21, TIMM23, TIMM50 Import motorProtein import, sorting and homeostasis > Protein import and sorting > Import motorDNAJC15, DNAJC19, GRPEL1, GRPEL2, PAM16, TIMM44 OXAProtein import, sorting and homeostasis > Protein import and sorting > OXAOXA1L Preprotein cleavageProtein import, sorting and homeostasis > Protein import and sorting > Preprotein cleavageIMMP1L, IMMP2L, MIPEP, PMPCA, PMPCB, UQCRC1, UQCRC2, XPNPEP3 Protein homeostasisProtein import, sorting and homeostasis > Protein homeostasisAFG1L, AFG3L2, ATAD1, ATP23, CASP3, CASP8, CASP9, CLPB, CLPP, CLPX, DNAJA3, DNAJC4, DNLZ, FKBP10, HSPD1, HSPE1, HTRA2, IDE, IMMP1L, IMMP2L, LACTB, LAP3, LONP1, MAIP1, METAP1D, MIPEP, MUL1, NLN, NRDC, OMA1, PARK7, PARL, PDF, PHB, PHB2, PITRM1, PMPCA, PMPCB, PRSS35, SPG7, STOML2, TIMM10, TIMM10B, TIMM13, TIMM8A, TIMM8B, TIMM9, TRAP1, USP30, XPNPEP3, YME1L1 ProteasesProtein import, sorting and homeostasis > Protein homeostasis > ProteasesAFG1L, AFG3L2, ATAD1, ATP23, CASP3, CASP9, CLPB, CLPP, CLPX, HTRA2, IDE, IMMP1L, IMMP2L, LACTB, LAP3, LONP1, METAP1D, MIPEP, NLN, OMA1, PARL, PITRM1, PMPCA, PMPCB, SPG7, USP30, XPNPEP3, YME1L1 ChaperonesProtein import, sorting and homeostasis > Protein homeostasis > ChaperonesDNAJA3, DNLZ, FKBP10, HSPD1, HSPE1, MAIP1, NRDC, PHB, PHB2, TIMM10, TIMM10B, TIMM13, TIMM8A, TIMM8B, TIMM9, TRAP1 OXPHOSOXPHOSACAD9, AIFM1, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5IF1, ATP5MC1, ATP5MC2, ATP5MC3, ATP5MD, ATP5ME, ATP5MF, ATP5MG, ATP5MPL, ATP5PB, ATP5PD, ATP5PF, ATP5PO, ATPAF1, ATPAF2, ATPSCKMT, BCS1L, CEP89, CMC1, CMC2, COA1, COA3, COA4, COA5, COA6, COA7, COA8, COX10, COX11, COX14, COX15, COX16, COX17, COX18, COX19, COX20, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYCS, DMAC1, DMAC2, DMAC2L, ECSIT, FMC1, FOXRED1, HCCS, HIGD1A, HIGD2A, LYRM2, LYRM7, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFAF8, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NUBPL, PET100, PET117, PNKD, RAB5IF, SCO1, SCO2, SDHA, SDHAF1, SDHAF2, SDHAF3, SDHAF4, SDHB, SDHC, SDHD, SMIM20, SURF1, TACO1, TIMM21, TIMMDC1, TMEM126A, TMEM126B, TMEM177, TMEM186, TMEM70, TTC19, UQCC1, UQCC2, UQCC3, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ OXPHOSsubunitsOXPHOS > OXPHOS subunitsATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5IF1, ATP5MC1, ATP5MC2, ATP5MC3, ATP5MD, ATP5ME, ATP5MF, ATP5MG, ATP5MPL, ATP5PB, ATP5PD, ATP5PF, ATP5PO, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYCS, DMAC2L, HCCS, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, SDHA, SDHB, SDHC, SDHD, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ OXPHOS assembly factorsOXPHOS > OXPHOS assembly factorsACAD9, AIFM1, ATPAF1, ATPAF2, ATPSCKMT, BCS1L, CEP89, CMC1, CMC2, COA1, COA3, COA4, COA5, COA6, COA7, COA8, COX10, COX11, COX14, COX15, COX16, COX17, COX18, COX19, COX20, COX7A2L, DMAC1, DMAC2, ECSIT, FMC1, FOXRED1, HIGD1A, HIGD2A, LYRM2, LYRM7, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFAF8, NUBPL, PET100, PET117, PNKD, RAB5IF, SCO1, SCO2, SDHAF1, SDHAF2, SDHAF3, SDHAF4, SMIM20, SURF1, TACO1, TIMM21, TIMMDC1, TMEM126A, TMEM126B, TMEM177, TMEM186, TMEM70, TTC19, UQCC1, UQCC2, UQCC3 Complex IOXPHOS > Complex IACAD9, AIFM1, COA1, DMAC1, DMAC2, ECSIT, FOXRED1, LYRM2, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFAF8, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NUBPL, TIMMDC1, TMEM126A, TMEM126B, TMEM186, TMEM70 CI subunitsOXPHOS > Complex I > CI subunitsMT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3 CI assembly factorsOXPHOS > Complex I > CI assembly factorsACAD9, AIFM1, COA1, DMAC1, DMAC2, ECSIT, FOXRED1, LYRM2, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFAF7, NDUFAF8, NUBPL, TIMMDC1, TMEM126A, TMEM126B, TMEM186, TMEM70 Complex IIOXPHOS > Complex IISDHA, SDHAF1, SDHAF2, SDHAF3, SDHAF4, SDHB, SDHC, SDHD CII subunitsOXPHOS > Complex II > CII subunitsSDHA, SDHB, SDHC, SDHD CII assembly factorsOXPHOS > Complex II > CII assembly factorsSDHAF1, SDHAF2, SDHAF3, SDHAF4 Complex IIIOXPHOS > Complex IIIBCS1L, CYC1, LYRM7, MT-CYB, TTC19, UQCC1, UQCC2, UQCC3, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ CIII subunitsOXPHOS > Complex III > CIII subunitsCYC1, MT-CYB, UQCR10, UQCR11, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ CIII assembly factorsOXPHOS > Complex III > CIII assembly factorsBCS1L, LYRM7, TTC19, UQCC1, UQCC2, UQCC3 Complex IVOXPHOS > Complex IVCEP89, CMC1, CMC2, COA1, COA3, COA4, COA5, COA6, COA7, COA8, COX10, COX11, COX14, COX15, COX16, COX17, COX18, COX19, COX20, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8A, COX8C, HIGD1A, MT-CO1, MT-CO2, MT-CO3, NDUFA4, PET100, PET117, PNKD, SCO1, SCO2, SMIM20, SURF1, TACO1, TIMM21, TMEM177 CIV subunitsOXPHOS > Complex IV > CIV subunitsCOX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7A2L, COX7B, COX7B2, COX7C, COX8A, COX8C, MT-CO1, MT-CO2, MT-CO3, NDUFA4 CIV assembly factorsOXPHOS > Complex IV > CIV assembly factorsCEP89, CMC1, CMC2, COA1, COA3, COA4, COA5, COA6, COA7, COA8, COX10, COX11, COX14, COX15, COX16, COX17, COX18, COX19, COX20, HIGD1A, PET100, PET117, PNKD, SCO1, SCO2, SMIM20, SURF1, TACO1, TIMM21, TMEM177 Complex VOXPHOS > Complex VATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5IF1, ATP5MC1, ATP5MC2, ATP5MC3, ATP5MD, ATP5ME, ATP5MF, ATP5MG, ATP5MPL, ATP5PB, ATP5PD, ATP5PF, ATP5PO, ATPAF1, ATPAF2, ATPSCKMT, DMAC2L, FMC1, MT-ATP6, MT-ATP8, TMEM70 CV subunitsOXPHOS > Complex V > CV subunitsATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5IF1, ATP5MC1, ATP5MC2, ATP5MC3, ATP5MD, ATP5ME, ATP5MF, ATP5MG, ATP5MPL, ATP5PB, ATP5PD, ATP5PF, ATP5PO, DMAC2L, MT-ATP6, MT-ATP8 CV assembly factorsOXPHOS > Complex V > CV assembly factorsATPAF1, ATPAF2, ATPSCKMT, FMC1, TMEM70 Respirasome assemblyOXPHOS > Respirasome assemblyCOX7A2L, HIGD1A, HIGD2A, RAB5IF Cytochrome COXPHOS > Cytochrome CCYCS, HCCS MetabolismMetabolismAADAT, AASS, ABAT, ABCB10, ABCB6, ABCB7, ABHD10, ABHD11, ACAA1, ACAA2, ACACA, ACACB, ACAD10, ACAD11, ACAD8, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACLY, ACO2, ACOD1, ACOT11, ACOT13, ACOT2, ACOT7, ACOT9, ACP6, ACSF2, ACSF3, ACSL1, ACSL6, ACSM1, ACSM2A, ACSM2B, ACSM3, ACSM4, ACSM5, ACSS1, ACSS3, ADHFE1, AGK, AGMAT, AGPAT4, AGPAT5, AGXT, AGXT2, AIFM2, AIFM3, AK2, AK3, AK4, AKR1B10, AKR7A2, ALAS1, ALAS2, ALDH18A1, ALDH1B1, ALDH1L1, ALDH1L2, ALDH2, ALDH3A2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH9A1, AMACR, AMT, ANTKMT, ARG2, AUH, BCAT2, BCKDHA, BCKDHB, BCKDK, BCO2, BDH1, BOLA1, BOLA3, BPHL, CA5A, CA5B, CAT, CBR3, CBR4, CHCHD7, CHDH, CHPT1, CISD1, CISD3, CKMT1A, CKMT1B, CKMT2, CLYBL, CMPK2, COASY, COMT, COQ10A, COQ10B, COQ2, COQ3, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ8B, COQ9, COX10, COX11, COX15, COX17, COX19, CPOX, CPS1, CPT1A, CPT1B, CPT1C, CPT2, CRAT, CRLS1, CROT, CS, CYB5B, CYB5R3, CYC1, CYCS, CYP11A1, CYP11B1, CYP11B2, CYP24A1, CYP27A1, CYP27B1, D2HGDH, DBI, DBT, DCXR, DECR1, DGLUCY, DGUOK, DHODH, DHRS1, DHRS2, DHRS4, DHTKD1, DLAT, DLD, DLST, DMGDH, DNA2, DTYMK, DUT, ECH1, ECHDC1, ECHS1, ECI1, ECI2, EHHADH, EPHX2, ETFA, ETFB, ETFBKMT, ETFDH, ETFRF1, ETHE1, FABP1, FAHD1, FAM210B, FASN, FDPS, FDX1, FDX2, FDXR, FECH, FH, FHIT, FLAD1, FPGS, FTH1, FTMT, FXN, GATM, GCAT, GCDH, GCSH, GLDC, GLRX2, GLRX5, GLS, GLS2, GLUD1, GLUD2, GLYAT, GLYCTK, GOT2, GPAM, GPAT2, GPD2, GPT2, GPX1, GPX4, GRHPR, GRPEL1, GRPEL2, GSR, GSTK1, GSTZ1, GTPBP3, GUK1, HADH, HADHA, HADHB, HAGH, HAO2, HCCS, HIBADH, HIBCH, HINT1, HINT2, HMGCL, HMGCS2, HOGA1, HSCB, HSD17B10, HSD17B4, HSD17B8, HSPA9, HTD2, IBA57, IDH2, IDH3A, IDH3B, IDH3G, IDI1, ISCA1, ISCA2, ISCU, IVD, KMO, KYAT3, L2HGDH, LACTB, LDHAL6B, LDHB, LDHD, LIAS, LIPT1, LIPT2, LYPLA1, LYPLAL1, LYRM4, MAOA, MAOB, MCAT, MCCC1, MCCC2, MCEE, MDH2, ME2, ME3, MECR, MGST1, MGST3, MLYCD, MMAA, MMAB, MMADHC, MMUT, MOCS1, MPC1, MPC1L, MPC2, MPST, MRPS36, MSRA, MSRB2, MSRB3, MT-CO1, MT-CYB, MTARC1, MTARC2, MTFMT, MTHFD1L, MTHFD2, MTHFD2L, MTHFS, MTO1, NADK2, NAGS, NAT8L, NAXD, NAXE, NDUFAB1, NDUFS1, NDUFS2, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NEU4, NFS1, NFU1, NIT1, NIT2, NME3, NME4, NME6, NMNAT3, NNT, NOCT, NT5DC2, NT5M, NTHL1, NUBPL, NUDT13, NUDT19, NUDT2, NUDT5, NUDT8, NUDT9, OAT, OGDH, OGDHL, OSBPL1A, OTC, OXCT1, OXCT2, OXR1, OXSM, PAICS, PANK2, PC, PCBD2, PCCA, PCCB, PCK2, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP1, PDP2, PDPR, PDSS1, PDSS2, PGS1, PHYH, PISD, PLD6, PLPBP, PLSCR3, PNPLA8, PNPO, PPA2, PPM1K, PPOX, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6, PRELID1, PRELID3A, PRELID3B, PRODH, PRODH2, PRXL2A, PTGES2, PTPMT1, PYCR1, PYCR2, QDPR, RDH13, RDH14, RFK, RPIA, RSAD1, SARDH, SCO1, SCO2, SCP2, SDHA, SDHB, SDHC, SDHD, SDSL, SELENOO, SERAC1, SFXN1, SFXN3, SFXN5, SHMT2, SIRT3, SIRT4, SIRT5, SLC25A1, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A19, SLC25A20, SLC25A21, SLC25A23, SLC25A24, SLC25A25, SLC25A28, SLC25A29, SLC25A3, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A36, SLC25A37, SLC25A38, SLC25A4, SLC25A41, SLC25A42, SLC25A44, SLC25A5, SLC25A51, SLC25A52, SLC25A6, SOD1, SOD2, SPHK2, SPR, SPTLC2, SQOR, STAR, STARD7, SUCLA2, SUCLG1, SUCLG2, SUGCT, SUOX, TAMM41, TAZ, THEM4, THEM5, TK2, TMLHE, TRIAP1, TSPO, TST, TSTD1, TXN2, TXNRD1, TXNRD2, UQCRFS1, ZADH2 Carbohydrate metabolismMetabolism > Carbohydrate metabolismABHD11, ACAA2, ACAT1, ACLY, ACO2, ACOD1, AUH, BDH1, CLYBL, CS, D2HGDH, DCXR, DLAT, DLD, DLST, FAHD1, FH, GLYCTK, GOT2, GPD2, HADHB, HMGCL, HMGCS2, IDH2, IDH3A, IDH3B, IDH3G, L2HGDH, LDHAL6B, LDHD, MCEE, MDH2, ME2, ME3, MMUT, MPC1, MPC1L, MPC2, MRPS36, NEU4, OGDH, OGDHL, OXCT1, OXCT2, PC, PCCA, PCCB, PCK2, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP1, PDP2, PDPR, RPIA, SDHA, SDHB, SDHC, SDHD, SFXN5, SLC25A1, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SUCLA2, SUCLG1, SUCLG2 GluconeogenesisMetabolism > Carbohydrate metabolism > GluconeogenesisMDH2, MPC1, MPC1L, MPC2, PC, PCK2, SLC25A1, SLC25A10, SLC25A11 Malate-aspartate shuttleMetabolism > Carbohydrate metabolism > Malate-aspartate shuttleGOT2, MDH2, SLC25A10, SLC25A11, SLC25A12, SLC25A13 Glycerol phosphate shuttleMetabolism > Carbohydrate metabolism > Glycerol phosphate shuttleGPD2 Pyruvate metabolismMetabolism > Carbohydrate metabolism > Pyruvate metabolismDLAT, DLD, MPC1, MPC1L, MPC2, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP1, PDP2, PDPR TCA cycleMetabolism > Carbohydrate metabolism > TCA cycleACO2, CS, DLD, DLST, FH, IDH2, IDH3A, IDH3B, IDH3G, MDH2, MRPS36, OGDH, OGDHL, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 TCA-associatedMetabolism > Carbohydrate metabolism > TCA-associatedABHD11, ACLY, D2HGDH, FAHD1, L2HGDH, ME2, ME3, MPC1, MPC1L, MPC2, PC, PCK2, SFXN5, SLC25A1, SLC25A11 Itaconate metabolismMetabolism > Carbohydrate metabolism > Itaconate metabolismACOD1, AUH, CLYBL, SUCLA2, SUCLG1, SUCLG2 Ketone metabolismMetabolism > Carbohydrate metabolism > Ketone metabolismACAA2, ACAT1, BDH1, HADHB, HMGCL, HMGCS2, OXCT1, OXCT2 Propanoate metabolismMetabolism > Carbohydrate metabolism > Propanoate metabolismMCEE, MMUT, PCCA, PCCB Lipid metabolismMetabolism > Lipid metabolismACAA1, ACAA2, ACACA, ACACB, ACAD10, ACAD11, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACOT11, ACOT13, ACOT2, ACOT7, ACOT9, ACP6, ACSF2, ACSF3, ACSL1, ACSL6, ACSM1, ACSM2A, ACSM2B, ACSM3, ACSM4, ACSM5, ACSS1, ACSS3, AGK, AGPAT4, AGPAT5, AMACR, CBR4, CHPT1, CPT1A, CPT1B, CPT1C, CPT2, CRAT, CRLS1, CROT, CYB5R3, CYP11A1, CYP11B1, CYP11B2, CYP27A1, DBI, DECR1, DHRS1, ECH1, ECHDC1, ECHS1, ECI1, ECI2, EHHADH, EPHX2, ETFA, ETFB, ETFDH, FABP1, FASN, FDPS, FDX1, FDXR, GCSH, GPAM, GPAT2, HADH, HADHA, HADHB, HAO2, HINT2, HSD17B10, HSD17B4, HSD17B8, HTD2, IDI1, LACTB, LIAS, LIPT1, LIPT2, LYPLA1, LYPLAL1, MCAT, MCEE, MECR, MGST3, MLYCD, MMUT, NDUFAB1, OSBPL1A, OXSM, PCCA, PCCB, PGS1, PHYH, PISD, PLD6, PLSCR3, PNPLA8, PRDX6, PRELID1, PRELID3A, PRELID3B, PTGES2, PTPMT1, SCP2, SERAC1, SLC25A1, SLC25A20, SPHK2, SPTLC2, STAR, STARD7, TAMM41, TAZ, THEM4, THEM5, TRIAP1, TSPO, ZADH2 Fatty acid oxidationMetabolism > Lipid metabolism > Fatty acid oxidationACAA2, ACACB, ACAD10, ACAD11, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACOT11, ACSF2, ACSL1, ACSL6, ACSM1, ACSM2A, ACSM2B, ACSM3, ACSM4, ACSM5, ACSS1, AMACR, CPT1A, CPT1B, CPT1C, CPT2, CRAT, CROT, DECR1, ECHS1, ECI1, ECI2, ETFA, ETFB, ETFDH, HADH, HADHA, HADHB, HSD17B10, MCEE, MMUT, PCCA, PCCB, SLC25A20 Type II fatty acid synthesisMetabolism > Lipid metabolism > Type II fatty acid synthesisACACA, ACSF3, CBR4, HSD17B8, HTD2, MCAT, MECR, NDUFAB1, OXSM Lipoate insertionMetabolism > Lipid metabolism > Lipoate insertionGCSH, LIAS, LIPT1, LIPT2 Cardiolipin synthesisMetabolism > Lipid metabolism > Cardiolipin synthesisAGPAT4, AGPAT5, CRLS1, GPAM, GPAT2, HADHA, PGS1, PLD6, PLSCR3, PNPLA8, PRELID1, PRELID3A, PTPMT1, TAMM41, TAZ, TRIAP1 Cholesterol, bile acid, steroid synthesisMetabolism > Lipid metabolism > Cholesterol, bile acid, steroid synthesisCYP11A1, CYP11B1, CYP11B2, CYP27A1, DHRS1, FDX1, FDXR, HINT2, HSD17B10, HSD17B8, OSBPL1A, SCP2, STAR, TSPO Cholesterol-associatedMetabolism > Lipid metabolism > Cholesterol-associatedFDPS, IDI1 Phospholipid metabolismMetabolism > Lipid metabolism > Phospholipid metabolismACP6, AGK, AGPAT4, AGPAT5, CHPT1, GPAM, GPAT2, LACTB, OSBPL1A, PGS1, PISD, PNPLA8, PRDX6, PRELID1, PRELID3A, PRELID3B, PTPMT1, SERAC1, SPHK2, SPTLC2, STARD7, TAMM41, TRIAP1 Eicosanoid metabolismMetabolism > Lipid metabolism > Eicosanoid metabolismMGST3, PTGES2, ZADH2 Amino acid metabolismMetabolism > Amino acid metabolismAADAT, AASS, ABAT, ACAA2, ACAD8, ACADSB, ACAT1, ADHFE1, AGMAT, AGXT, AGXT2, AKR7A2, ALDH18A1, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH9A1, AMT, ARG2, AUH, BCAT2, BCKDHA, BCKDHB, BCKDK, CA5A, CA5B, CHDH, COMT, CPS1, DBT, DGLUCY, DHTKD1, DLD, DLST, DMGDH, ECHS1, ETFA, ETFB, ETFDH, GCAT, GCDH, GCSH, GLDC, GLS, GLS2, GLUD1, GLUD2, GLYAT, GOT2, GPT2, GRHPR, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HOGA1, HSD17B10, IVD, KMO, KYAT3, LDHB, MAOA, MAOB, MCCC1, MCCC2, NAGS, NAT8L, OAT, OTC, PPM1K, PRODH, PRODH2, PYCR1, PYCR2, SARDH, SDSL, SFXN1, SFXN3, SHMT2, SLC25A12, SLC25A13, SLC25A15, SLC25A21, SLC25A29, SLC25A38, SLC25A44, SUGCT Branched-chain amino acid metabolismMetabolism > Amino acid metabolism > Branched-chain amino acid metabolismACAD8, ACADSB, ACAT1, ALDH6A1, AUH, BCAT2, BCKDHA, BCKDHB, BCKDK, DBT, DLD, ECHS1, ETFA, ETFB, ETFDH, HADHA, HIBADH, HIBCH, HMGCL, HSD17B10, IVD, MCCC1, MCCC2, PPM1K, SLC25A44 Branched-chain amino acid dehydrogenase complexMetabolism > Amino acid metabolism > Branched-chain amino acid dehydrogenase complexBCKDHA, BCKDHB, BCKDK, DBT, DLD, PPM1K Lysine metabolismMetabolism > Amino acid metabolism > Lysine metabolismAADAT, AASS, ACAA2, ACAT1, ALDH7A1, DHTKD1, DLD, DLST, ECHS1, ETFA, ETFB, ETFDH, GCDH, HADH, HADHB, SLC25A29 Serine metabolismMetabolism > Amino acid metabolism > Serine metabolismAGXT, SDSL, SFXN1, SFXN3, SHMT2 Glycine metabolismMetabolism > Amino acid metabolism > Glycine metabolismALDH7A1, AMT, CHDH, DLD, DMGDH, ETFA, ETFB, ETFDH, GCAT, GCSH, GLDC, GLYAT, SARDH, SHMT2, SLC25A38 Glycine cleavage systemMetabolism > Amino acid metabolism > Glycine cleavage systemAMT, DLD, GCSH, GLDC Glutamate metabolismMetabolism > Amino acid metabolism > Glutamate metabolismGLS, GLS2, GLUD1, GLUD2, GOT2, GPT2, NAT8L, SLC25A12 Proline metabolismMetabolism > Amino acid metabolism > Proline metabolismALDH18A1, ALDH4A1, OAT, PRODH, PYCR1, PYCR2 Glyoxylate metabolismMetabolism > Amino acid metabolism > Glyoxylate metabolismAGXT, AGXT2, ALDH4A1, GOT2, GRHPR, HOGA1, LDHB, PRODH2 GABA metabolismMetabolism > Amino acid metabolism > GABA metabolismABAT, ADHFE1, AKR7A2, ALDH5A1, ALDH9A1, GLUD1, GLUD2 Catechol metabolismMetabolism > Amino acid metabolism > Catechol metabolismCOMT, MAOA, MAOB Kynurenine metabolismMetabolism > Amino acid metabolism > Kynurenine metabolismGOT2, KMO, KYAT3 Urea cycleMetabolism > Amino acid metabolism > Urea cycleCA5A, CA5B, CPS1, NAGS, OTC, SLC25A13, SLC25A15 Nucleotide metabolismMetabolism > Nucleotide metabolismAK2, AK3, AK4, ANTKMT, CKMT1A, CKMT1B, CKMT2, CMPK2, DGUOK, DHODH, DTYMK, DUT, FHIT, GATM, GUK1, HINT1, NME3, NME4, NME6, NT5DC2, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PPA2, SLC25A23, SLC25A24, SLC25A25, SLC25A31, SLC25A33, SLC25A36, SLC25A4, SLC25A41, SLC25A5, SLC25A6, SUCLA2, SUCLG1, TK2 Nucleotide importMetabolism > Nucleotide metabolism > Nucleotide importSLC25A23, SLC25A24, SLC25A25, SLC25A31, SLC25A33, SLC25A36, SLC25A4, SLC25A41, SLC25A5, SLC25A6 Nucleotide synthesis and processingMetabolism > Nucleotide metabolism > Nucleotide synthesis and processingAK2, AK3, AK4, CMPK2, DGUOK, DHODH, DTYMK, DUT, FHIT, GUK1, HINT1, NME3, NME4, NME6, NT5DC2, NT5M, NUDT2, NUDT5, NUDT9, PAICS, SUCLA2, SUCLG1, TK2 Creatine metabolismMetabolism > Nucleotide metabolism > Creatine metabolismCKMT1A, CKMT1B, CKMT2, GATM Metals and cofactorsMetabolism > Metals and cofactorsABAT, ABCB10, ABCB6, ABCB7, ACO2, AIFM3, ALAS1, ALAS2, BOLA1, BOLA3, CHCHD7, CISD1, CISD3, COASY, COQ10A, COQ10B, COQ2, COQ3, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ8B, COQ9, COX10, COX11, COX15, COX17, COX19, CPOX, CPT1A, CPT1B, CPT1C, CPT2, CYB5B, CYC1, CYCS, CYP11A1, CYP11B1, CYP11B2, CYP24A1, CYP27A1, CYP27B1, DNA2, ETFDH, FABP1, FAM210B, FDX1, FDX2, FDXR, FECH, FTH1, FTMT, FXN, GLRX2, GLRX5, GRPEL1, GRPEL2, HCCS, HSCB, HSPA9, IBA57, ISCA1, ISCA2, ISCU, KMO, KYAT3, LIAS, LYRM4, MOCS1, MT-CO1, MT-CYB, MTARC1, MTARC2, NADK2, NAXD, NAXE, NDUFAB1, NDUFS1, NDUFS2, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NFS1, NFU1, NMNAT3, NNT, NOCT, NTHL1, NUBPL, NUDT13, NUDT19, NUDT8, PANK2, PCBD2, PDSS1, PDSS2, PPOX, QDPR, RSAD1, SCO1, SCO2, SDHB, SDHC, SDHD, SIRT3, SIRT4, SIRT5, SLC25A20, SLC25A28, SLC25A3, SLC25A37, SLC25A38, SLC25A42, SLC25A51, SLC25A52, SPR, SUOX, TMLHE, UQCRFS1 Carnitine synthesis and transportMetabolism > Metals and cofactors > Carnitine synthesis and transportCPT1A, CPT1B, CPT1C, CPT2, SLC25A20, TMLHE Carnitine shuttleMetabolism > Metals and cofactors > Carnitine shuttleCPT1A, CPT1B, CPT1C, CPT2, SLC25A20 Coenzyme A metabolismMetabolism > Metals and cofactors > Coenzyme A metabolismCOASY, NUDT19, NUDT8, PANK2, SLC25A42 Coenzyme Q metabolismMetabolism > Metals and cofactors > Coenzyme Q metabolismCOQ10A, COQ10B, COQ2, COQ3, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ8B, COQ9, PDSS1, PDSS2 Copper metabolismMetabolism > Metals and cofactors > Copper metabolismCHCHD7, COX11, COX17, COX19, SCO1, SCO2, SLC25A3 Iron homeostasisMetabolism > Metals and cofactors > Iron homeostasisFAM210B, FTH1, FTMT, SLC25A28, SLC25A37 Heme synthesis and processingMetabolism > Metals and cofactors > Heme synthesis and processingABCB10, ABCB6, ABCB7, ALAS1, ALAS2, COX10, COX15, CPOX, FABP1, FDX1, FDX2, FDXR, FECH, HCCS, PPOX, SLC25A38 Fe-S cluster biosynthesisMetabolism > Metals and cofactors > Fe-S cluster biosynthesisABCB7, BOLA1, BOLA3, CISD1, CISD3, FDX1, FDX2, FDXR, FXN, GLRX5, GRPEL1, GRPEL2, HSCB, HSPA9, IBA57, ISCA1, ISCA2, ISCU, LYRM4, NDUFAB1, NFS1, NFU1, NUBPL Molybdenum cofactor synthesis and proteinsMetabolism > Metals and cofactors > Molybdenum cofactor synthesis and proteinsABCB7, MOCS1, MTARC1, MTARC2, SUOX NAD biosynthesis and metabolismMetabolism > Metals and cofactors > NAD biosynthesis and metabolismKMO, KYAT3, NADK2, NAXD, NAXE, NMNAT3, NNT, NOCT, NUDT13, SIRT3, SIRT4, SIRT5, SLC25A51, SLC25A52 Tetrahydrobiopterin synthesisMetabolism > Metals and cofactors > Tetrahydrobiopterin synthesisPCBD2, QDPR, SPR Fe-S-containing proteinsMetabolism > Metals and cofactors > Fe-S-containing proteinsABAT, ACO2, AIFM3, BOLA1, BOLA3, CISD1, CISD3, DNA2, ETFDH, FDX1, FDX2, FECH, GLRX2, GLRX5, ISCA1, ISCA2, ISCU, LIAS, NDUFS1, NDUFS2, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NFS1, NFU1, NTHL1, NUBPL, RSAD1, SDHB, UQCRFS1 Heme-containing proteinsMetabolism > Metals and cofactors > Heme-containing proteinsCYB5B, CYC1, CYCS, CYP11A1, CYP11B1, CYP11B2, CYP24A1, CYP27A1, CYP27B1, MT-CO1, MT-CYB, SDHC, SDHD Vitamin metabolismMetabolism > Vitamin metabolismACACA, ACACB, AKR1B10, ALDH1L1, ALDH1L2, ALDH7A1, AMT, BCO2, CHDH, CYP24A1, CYP27B1, DHRS4, DMGDH, ETFA, ETFB, ETFDH, FDX1, FDXR, FLAD1, FPGS, GLRX2, GTPBP3, MCCC1, MMAA, MMAB, MMADHC, MMUT, MTFMT, MTHFD1L, MTHFD2, MTHFD2L, MTHFS, MTO1, PC, PCCA, PLPBP, PNPO, QDPR, RDH13, RDH14, RFK, SARDH, SFXN1, SFXN3, SHMT2, SLC25A19, SLC25A32, SLC25A38, TXN2 Choline and betaine metabolismMetabolism > Vitamin metabolism > Choline and betaine metabolismALDH7A1, CHDH, DMGDH, ETFA, ETFB, ETFDH, SARDH Biotin utilizing proteinsMetabolism > Vitamin metabolism > Biotin utilizing proteinsACACA, ACACB, MCCC1, PC, PCCA Vitamin A metabolismMetabolism > Vitamin metabolism > Vitamin A metabolismAKR1B10, BCO2, DHRS4, RDH13, RDH14 Vitamin B1 metabolismMetabolism > Vitamin metabolism > Vitamin B1 metabolismSLC25A19 Vitamin B2 metabolismMetabolism > Vitamin metabolism > Vitamin B2 metabolismFLAD1, RFK, SLC25A32 Vitamin B6 metabolismMetabolism > Vitamin metabolism > Vitamin B6 metabolismPLPBP, PNPO Vitamin B12 metabolismMetabolism > Vitamin metabolism > Vitamin B12 metabolismMMAA, MMAB, MMADHC, MMUT Vitamin C metabolismMetabolism > Vitamin metabolism > Vitamin C metabolismGLRX2, TXN2 Vitamin D metabolismMetabolism > Vitamin metabolism > Vitamin D metabolismCYP24A1, CYP27B1, FDX1, FDXR Folate and 1-C metabolismMetabolism > Vitamin metabolism > Folate and 1-C metabolismALDH1L1, ALDH1L2, ALDH7A1, AMT, CHDH, DMGDH, FPGS, GTPBP3, MTFMT, MTHFD1L, MTHFD2, MTHFD2L, MTHFS, MTO1, QDPR, SARDH, SFXN1, SFXN3, SHMT2, SLC25A32, SLC25A38 DetoxificationMetabolism > DetoxificationABHD10, ACSM2A, ACSM5, AIFM2, AKR1B10, AKR7A2, ALDH1B1, ALDH2, ALDH3A2, ALDH7A1, ALDH9A1, BPHL, CAT, CBR3, CYB5B, CYB5R3, DHRS2, EPHX2, GLRX2, GLYAT, GPX1, GPX4, GSR, GSTK1, GSTZ1, HAGH, MAOA, MAOB, MGST1, MPST, MSRA, MSRB2, MSRB3, MTARC1, MTARC2, NIT1, NIT2, OXR1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6, PRXL2A, SELENOO, SOD1, SOD2, TST, TXN2, TXNRD1, TXNRD2 Xenobiotic metabolismMetabolism > Detoxification > Xenobiotic metabolismABHD10, ACSM2A, ACSM5, AKR1B10, AKR7A2, ALDH1B1, ALDH2, BPHL, CBR3, CYB5B, CYB5R3, DHRS2, EPHX2, GLYAT, GSTK1, GSTZ1, MAOA, MAOB, MGST1, MPST, MTARC1, MTARC2, TST ROS and glutathione metabolismMetabolism > Detoxification > ROS and glutathione metabolismAIFM2, ALDH3A2, ALDH7A1, ALDH9A1, CAT, GLRX2, GPX1, GPX4, GSR, HAGH, MGST1, MSRA, MSRB2, MSRB3, NIT1, OXR1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6, PRXL2A, SOD1, SOD2, TXN2, TXNRD1, TXNRD2 Amidoxime reducing complexMetabolism > Detoxification > Amidoxime reducing complexCYB5B, CYB5R3, MTARC1, MTARC2 SelenoproteinsMetabolism > Detoxification > SelenoproteinsGPX1, GPX4, SELENOO, TXNRD1, TXNRD2 Electron carriersMetabolism > Electron carriersCHDH, CYB5B, CYC1, CYCS, DHODH, ETFA, ETFB, ETFBKMT, ETFDH, ETFRF1, GPD2, MT-CYB, PRODH, PRODH2, SQOR CytochromesMetabolism > Electron carriers > CytochromesCYB5B, CYC1, CYCS, MT-CYB Q-linked reactions, otherMetabolism > Electron carriers > Q-linked reactions, otherCHDH, DHODH, ETFA, ETFB, ETFBKMT, ETFDH, ETFRF1, GPD2, PRODH, PRODH2, SQOR Sulfur metabolismMetabolism > Sulfur metabolismETHE1, GOT2, MPST, MSRA, MSRB2, SLC25A14, SLC25A30, SQOR, SUOX, TST, TSTD1 Small molecule transportSmall molecule transportABCA9, ABCB10, ABCB6, ABCB7, ABCB8, ABCD1, ABCD2, ABCD3, CCDC51, LETMD1, MCU, MCUB, MICU1, MICU2, MICU3, MPC1, MPC1L, MPC2, MPV17, MPV17L, MRS2, MTCH1, MTCH2, ROMO1, SFXN1, SFXN2, SFXN3, SFXN4, SFXN5, SLC25A1, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A3, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A4, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46, SLC25A47, SLC25A48, SLC25A5, SLC25A51, SLC25A52, SLC25A53, SLC25A6, SLC30A9, SLC8B1, SMDT1, STARD7, UCP1, UCP2, UCP3, VDAC1, VDAC2, VDAC3 SLC25A familySmall molecule transport > SLC25A familyMTCH1, MTCH2, SLC25A1, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A3, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A4, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46, SLC25A47, SLC25A48, SLC25A5, SLC25A51, SLC25A52, SLC25A53, SLC25A6, UCP1, UCP2, UCP3 ABC transportersSmall molecule transport > ABC transportersABCA9, ABCB10, ABCB6, ABCB7, ABCB8, ABCD1, ABCD2, ABCD3 SideroflexinsSmall molecule transport > SideroflexinsSFXN1, SFXN2, SFXN3, SFXN4, SFXN5 SignalingSignalingACOD1, ADCY10, AKAP1, AKAP10, BLOC1S1, C1QBP, CSKMT, DELE1, EFHD1, FUNDC2, IFI27, LETM1, LYPLA1, MACROD1, MAVS, MCRIP2, MCU, MCUB, MICU1, MICU2, MICU3, MRS2, MUL1, NLRX1, OCIAD2, PDE2A, PINK1, PPIF, PPTC7, PRKACA, RHOT1, RHOT2, SIRT3, SLC25A12, SLC25A13, SLC25A23, SLC25A24, SLC25A25, SLC25A3, SLC25A31, SLC25A4, SLC25A5, SLC25A6, SLC8B1, SMDT1, SPHKAP, VDAC1, VDAC3 Calcium homeostasisSignaling > Calcium homeostasisEFHD1, LETM1, MCU, MCUB, MICU1, MICU2, MICU3, PPIF, RHOT1, RHOT2, SLC25A12, SLC25A13, SLC25A23, SLC25A24, SLC25A25, SLC25A3, SLC25A31, SLC25A4, SLC25A5, SLC25A6, SLC8B1, SMDT1, VDAC1, VDAC3 Calcium uniporterSignaling > Calcium homeostasis > Calcium uniporter  Small molecule transport > Calcium uniporterMCU, MCUB, MICU1, MICU2, MICU3, SMDT1 Calcium cycleSignaling > Calcium homeostasis > Calcium cycleLETM1, MCU, MCUB, MICU1, MICU2, MICU3, SLC25A3, SLC8B1, SMDT1 Mitochondrial permeability transition poreSignaling > Calcium homeostasis > Mitochondrial permeability transition porePPIF, SLC25A31, SLC25A4, SLC25A5, SLC25A6, VDAC1, VDAC3 EF hand proteinsSignaling > Calcium homeostasis > EF hand proteinsEFHD1, MICU1, MICU2, MICU3, RHOT1, RHOT2, SLC25A12, SLC25A13, SLC25A23, SLC25A24, SLC25A25 Immune responseSignaling > Immune responseACOD1, C1QBP, IFI27, MAVS, NLRX1 cAMP-PKA signalingSignaling > cAMP-PKA signalingADCY10, AKAP1, AKAP10, PDE2A, PRKACA, SPHKAP Mitochondrial dynamics and surveillanceMitochondrial dynamics and surveillanceAHCYL1, AIFM1, AIFM2, AIFM3, APOO, APOOL, ARL2, ARMC10, ARMCX1, ARMCX3, ATAD3A, ATAD3B, ATP5MD, ATP5ME, ATP5MG, BAD, BAK1, BAX, BBC3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L13, BCL2L2, BID, BIK, BNIP3, BNIP3L, BOK, CASP3, CASP8, CASP9, CHCHD2, CHCHD3, CHCHD6, CYCS, DIABLO, DNAJC11, DNM1L, ENDOG, FIS1, FKBP8, FUNDC1, FUNDC2, GHITM, HTRA2, IFI27, IMMT, MARCHF5, MCL1, MFF, MFN1, MFN2, MGARP, MICOS10, MICOS13, MIEF1, MIEF2, MIGA1, MIGA2, MTCH2, MTFP1, MTFR1, MTFR2, MTX1, MTX2, MTX3, MUL1, MYO19, NBR1, NIPSNAP1, NIPSNAP2, OMA1, OPA1, PARK7, PARL, PGAM5, PIGBOS1, PINK1, PLD6, PMAIP1, PRKN, RAB24, RHOT1, RHOT2, RMDN3, RTL10, SAMM50, SEPTIN4, SLC25A46, SNAP29, SPHK2, SPIRE1, STX17, STYXL1, SYNJ2BP, TMEM11, TOMM20, TOMM7, USP30, VDAC1, VPS13D FusionMitochondrial dynamics and surveillance > FusionARL2, MFN1, MFN2, MIGA1, MIGA2, MTCH2, OMA1, OPA1, PLD6 FissionMitochondrial dynamics and surveillance > FissionARMC10, DNM1L, FIS1, MFF, MIEF1, MIEF2, MTFP1, MTFR1, MTFR2, MUL1, OMA1, RAB24, SLC25A46, SPIRE1, STX17 Organelle contact sitesMitochondrial dynamics and surveillance > Organelle contact sitesAHCYL1, ATAD3A, ATAD3B, FKBP8, FUNDC2, MFN1, MFN2, MIGA2, PIGBOS1, RMDN3, SPIRE1, STX17, SYNJ2BP, VDAC1 Intramitochondrial membrane interactionsMitochondrial dynamics and surveillance > Intramitochondrial membrane interactionsATAD3A, ATAD3B, CHCHD3, DNAJC11, MTX1, MTX2, MTX3, SAMM50, SLC25A46 TraffickingMitochondrial dynamics and surveillance > TraffickingARMC10, ARMCX1, ARMCX3, MGARP, MYO19, RHOT1, RHOT2 MitophagyMitochondrial dynamics and surveillance > MitophagyBCL2L13, FKBP8, FUNDC1, MARCHF5, NIPSNAP1, NIPSNAP2, PARK7, PARL, PGAM5, PINK1, PRKN, TOMM7, USP30, VPS13D AutophagyMitochondrial dynamics and surveillance > AutophagyBCL2L13, FKBP8, FUNDC1, MARCHF5, NBR1, NIPSNAP1, NIPSNAP2, PARK7, PARL, PGAM5, PINK1, PRKN, RAB24, SNAP29, STX17, TOMM7, USP30, VPS13D ApoptosisMitochondrial dynamics and surveillance > ApoptosisAIFM1, AIFM2, AIFM3, BAD, BAK1, BAX, BBC3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L13, BCL2L2, BID, BIK, BNIP3, BNIP3L, BOK, CASP3, CASP8, CASP9, CHCHD2, CYCS, DIABLO, ENDOG, GHITM, HTRA2, IFI27, MCL1, PMAIP1, RTL10, SEPTIN4, SPHK2, STYXL1 Cristae formationMitochondrial dynamics and surveillance > Cristae formationAPOO, APOOL, ATP5MD, ATP5ME, ATP5MG, CHCHD3, CHCHD6, IMMT, MICOS10, MICOS13, OPA1 MICOS complexMitochondrial dynamics and surveillance > Cristae formation > MICOS complexAPOO, APOOL, CHCHD3, CHCHD6, IMMT, MICOS10, MICOS13 2ff7e9595c
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